![office 2019 standard mak office 2019 standard mak](https://image.slidesharecdn.com/16ebe39736b-191202102047/95/best-product-microsoft-office-2019-professional-plus-inkl-tralion-dvd-inkl-lizenzdokumente-audit-sicher-review-948-1-638.jpg)
For instance, using data from twins, a Danish study reported more pronounced risk of stroke hospitalisation and stroke death among monozygotic co-twins compared with dizygotic co-twins, indicating that genetic factors increase the risk of stroke. Genetic factors have been demonstrated to play an important role in the development of CVD. Also, limited attentions have been paid on the potential differences in immediate- and long-term effects of cancer diagnosis on CVD, rendering difficulties on employment of cost-efficient interventions on CVD prevention. However, as most of previous studies were relied on register-based data and therefore lack of data on environmental and lifestyle factors, these analyses had insufficient control for many important confounders. Moreover, studies have consistently showed an association between a cancer diagnosis and subsequently increased risk of overall or specific subtypes of CVD, with possible explanations include that a cancer diagnosis, as a devastating event that usually comes with substantial psychological distress, can be a significant stressor that may trigger or facilitate the development or clinical presentation of CVD. An elevation in the risk of CVD has also been robustly observed among patients with stress-related disorders after a trauma exposure.
![office 2019 standard mak office 2019 standard mak](https://active-keys.ru/image/cache/catalog/office%202016/office_2019_professional_5pc-1200x800.jpg)
Growing evidence suggests that stressful events, such as natural disasters or the loss of a close relative, may lead to an increased risk of cardiovascular disease (CVD). Our findings suggest that patients with a recent cancer diagnosis were at an increased risk of multiple types of CVD and the excess CVD risk was higher among individuals with lower genetic susceptibility to CVD, highlighting a general need for enhanced psychological assistance and clinical surveillance of CVD among newly diagnosed cancer patients. For all the studied time periods, stratification analyses by both levels of polygenic risk score for CVD and by family history of CVD revealed higher estimates among individuals with lower genetic risk predisposition. Such excess risk was most pronounced (hazard ratio = 5.28, 95% confidence interval 4.90-5.69) within 3 months after a cancer diagnosis, which then decreased rapidly and stabilised for >6 months (HR = 1.22, 95% CI 1.19–1.24). Resultsĭuring nearly 23 years of follow-up, an elevated risk of CVD was constantly observed among cancer patients, compared to their matched unexposed individuals. We used Cox model to assess the subsequent relative risk of CVD, which was further stratified by individual genetic predisposition. We conducted a matched cohort study of UK Biobank including 78,860 individuals with a cancer diagnosis between January 1997 and January 2020, and 394,300 birth year and sex individually matched unexposed individuals. Evidence is scarce regarding the potential modifying role of disease susceptibility on the association between a prior cancer diagnosis and cardiovascular disease (CVD).